Resources

Sedation in ICU - a new paradigm

References mentioned in Interview

Shehabi, Yahya; Riker, Richard R. MD; Bokesch, Paula M. MD; et al. Delirium duration and mortality in lightly sedated, mechanically ventilated intensive care patients. Crit Care Med. 2010 Dec;38(12):2311-8.

Pandharipande PP, Sanders RD, Girard TD et al Effect of dexmedetomidine versus lorazepam on outcome in patients with sepsis: an a priori-designed analysis of the MENDS randomized controlled trial. Critical Care 2010;14(2):R38

Strøm T, Martinussen T, Toft P. A protocol of no sedation for critically ill patients receiving mechanical ventilation: a randomised trial. Lancet 2010; 375:475 - 480

Girard TD, Kress JP, Fuchs BD, et al. Efficacy and safety of a paired sedation and ventilation weaning protocol for mechanically ventilated patients in intensive care (Awakening and breathing controlled trial): a randomised controlled trial. Lancet. 2008;371:126-134

Riker RR, Shehabi Y, Bokesch PM, et al. Dexmedetomidine vs Midazolam for Sedation of Critically Ill Patients SEDCOM (Safety and Efficacy of Dexmedetomidine Compared with Midazolam) JAMA 2009; 301(5):489-99

Kress JP, Pohlman AS, O'Connor MF, Hall JB. Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation. New England Journal of Medicine, 2000 342(20):1471-7.

Kress JP, Gehlbach B, Lacy M, Pliskin N, Pohlman AS, Hall JB. The long-term psychological effects of daily sedative interruption on critically ill patients

American Journal of Respiratory and Critical Care Medicine, 2003; 168. pp. 1457-1461

Devlin JW, Roberts RJ, Fong JJ, Skrobik Y, Riker RR, Hill NS, Robbins T, Garpestad E. Efficacy and safety of quetiapine in critically ill patients with delirium: a prospective, multicenter, randomized, double-blind, placebo-controlled pilot study.

Crit Care Med. 2010 Feb;38(2):419-27.

Thomas N. Robinson, MD; Christopher D. Raeburn, MD; Zung V. Tran, PhD; Lisa A. Brenner, PhD; Marc Moss, MD Motor Subtypes of Postoperative Delirium in Older Adults Arch Surg. 2011;146(3):295-300.

Reade M, O'Sullivan K, Bates S et al. Dexmeditomidine vrs haloperidol in delirious, agitated, intubated patients : a randomised open label trialCritical Care 2009; 13 : R75

Other resources

Wes Ely's fantastic on-line delirium resource - www.icudelirium.org