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A 65 yr female is admitted to your ICU 10 days after elective cardiac surgery with sepsis secondary to sternal wound infection and a widespread rash.

Answer the following questions


  • Question 1
  • Question 2
  • Question 3
  • Question 4
  • Question 5

Her medications include vancomycin, meropenem, heparin, and pantoprazole.

ICU Day

1

5

7

10

Hb (g/dL)

105

95

90

91

Platelets

125

98

20

8

WCC 

11

10

8

9

List the most likely causes of her thrombocytopaenia.

Outline your management of her thrombocytopaenia

What tests would you perform to determine aetiology? Briefly outline the features of them.

On Day 10 the patient becomes tachypnoeic with abdominal tenderness. Current medications are meropenem, pantoprazole, noradrenaline, fentanyl and midazolam infusions. The following results and ECG are available;

pH

Lactate

HCO3

PaCO2

7.23

14 mmol/L

18 mol/L

28 mmHg

Platelets

WCC

Hb

INR

10

7

80

1.4

  • Describe the abnormalities on the blood results
  • Comment on the ECG
  • What are the likely causes of  the acid-base abnormality

What are the arguments for and against anticoagulation in this case?